Shinjuku
Marunouchi + Shinjuku + ŌedoA first visit built around the biggest interchange
Shinjuku layers three subway lines on top of the JR hub, so most day trips start without a transfer. The west side is office towers and large hotels; the east side is Kabukicho and the department stores.
Trade-off: The station complex is enormous, and a hotel labelled Shinjuku can still be a long underground walk from the platform you need. Compare Ikebukuro for lower prices on the same north-west corridor.
Before you book: Check which exit the hotel is nearest to and whether the walk is above or below ground. A routed walking figure beats a Shinjuku address.