Penn Station
Subway at 34th Street with Amtrak, LIRR and NJ TransitTrain arrivals, Madison Square Garden and Newark Airport
Penn Station is the Amtrak, LIRR and NJ Transit hub, which also makes it the rail route from Newark Airport. Subway lines on Seventh and Eighth avenues stop above it, and the Hudson Yards extension of the 7 train is a short walk.
Trade-off: The blocks around the station are busy and commercial rather than charming, and event nights at the Garden fill the streets.
Before you book: Check whether the hotel is on the Seventh or Eighth Avenue side; both are called Penn Station but serve different subway lines.